AP2A2-TSPAN4 Fusion FISH Probe
The AP2A2-TSPAN4 Fusion FISH Probe is used to confirm a fusion of the AP2A2 and TSPAN4 genes. The fusion of the AP2A2 and TSPAN4 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AP2A2-TSPAN4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-RERE | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-REOR | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-REGO | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-REGR | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-REAQ | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-ORRE | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-OROR | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-ORGO | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-ORAQ | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GORE | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GOOR | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GOGO | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GOGR | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GOAQ | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GRRE | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GROR | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GRGO | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GRGR | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-GRAQ | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-AQRE | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-AQOR | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-AQGO | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-AQGR | 20 (40 μL) | 200 μL |
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| AP2A2-TSPAN4-20-AQAQ | 20 (40 μL) | 200 μL |
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AP2A2 Gene Summary
The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. [provided by RefSeq, Nov 2016]
Gene Name: Adaptor Related Protein Complex 2 Alpha 2 Subunit
Chromosome: CHR11: 925808 -1012245
Locus: 11p15.5
TSPAN4 Gene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Tetraspanin 4
Chromosome: CHR11: 842823 -867116
Locus: 11p15.5
Gene Diseases
The AP2A2 TSPAN4 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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