AP2A2-TRIM22 Fusion FISH Probe
The AP2A2-TRIM22 Fusion FISH Probe is used to confirm a fusion of the AP2A2 and TRIM22 genes. The fusion of the AP2A2 and TRIM22 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AP2A2-TRIM22-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-RERE | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-REOR | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-REGO | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-REGR | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-REAQ | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-ORRE | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-OROR | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-ORGO | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-ORAQ | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GORE | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GOOR | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GOGO | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GOGR | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GOAQ | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GRRE | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GROR | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GRGO | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GRGR | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-GRAQ | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-AQRE | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-AQOR | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-AQGO | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-AQGR | 20 (40 μL) | 200 μL |
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| AP2A2-TRIM22-20-AQAQ | 20 (40 μL) | 200 μL |
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AP2A2 Gene Summary
The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. [provided by RefSeq, Nov 2016]
Gene Name: Adaptor Related Protein Complex 2 Alpha 2 Subunit
Chromosome: CHR11: 925808 -1012245
Locus: 11p15.5
TRIM22 Gene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Name: Tripartite Motif Containing 22
Chromosome: CHR11: 5710816 -5732093
Locus: 11p15.4
Gene Diseases
The AP2A2 TRIM22 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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