AP2A2-PSMD13 Fusion FISH Probe
The AP2A2-PSMD13 Fusion FISH Probe is used to confirm a fusion of the AP2A2 and PSMD13 genes. The fusion of the AP2A2 and PSMD13 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AP2A2-PSMD13-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-RERE | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-REOR | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-REGO | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-REGR | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-OROR | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GORE | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GROR | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| AP2A2-PSMD13-20-AQAQ | 20 (40 μL) | 200 μL |
|
AP2A2 Gene Summary
The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. [provided by RefSeq, Nov 2016]
Gene Name: Adaptor Related Protein Complex 2 Alpha 2 Subunit
Chromosome: CHR11: 925808 -1012245
Locus: 11p15.5
PSMD13 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: Proteasome 26S Subunit, Non-ATPase 13
Chromosome: CHR11: 236807 -252984
Locus: 11p15.5
Gene Diseases
The AP2A2 PSMD13 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|