AP2A1-DHDH Fusion FISH Probe
The AP2A1-DHDH Fusion FISH Probe is used to confirm a fusion of the AP2A1 and DHDH genes. The fusion of the AP2A1 and DHDH genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AP2A1-DHDH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-RERE | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-REOR | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-REGO | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-REGR | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-REAQ | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-ORRE | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-OROR | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-ORGO | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-ORAQ | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GORE | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GOOR | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GOGO | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GOGR | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GOAQ | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GRRE | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GROR | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GRGO | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GRGR | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-GRAQ | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-AQRE | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-AQOR | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-AQGO | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-AQGR | 20 (40 μL) | 200 μL |
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| AP2A1-DHDH-20-AQAQ | 20 (40 μL) | 200 μL |
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AP2A1 Gene Summary
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Adaptor Related Protein Complex 2 Alpha 1 Subunit
Chromosome: CHR19: 50270179 -50310369
Locus: 19q13.33
DHDH Gene Summary
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
Gene Name: Dihydrodiol Dehydrogenase
Chromosome: CHR19: 49436938 -49448226
Locus: 19q13.33
Gene Diseases
The AP2A1 DHDH Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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