AP1M1-RAB8A Fusion FISH Probe
The AP1M1-RAB8A Fusion FISH Probe is used to confirm a fusion of the AP1M1 and RAB8A genes. The fusion of the AP1M1 and RAB8A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AP1M1-RAB8A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-RERE | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-REOR | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-REGO | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-REGR | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-REAQ | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-ORRE | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-OROR | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-ORGO | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-ORAQ | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GORE | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GOOR | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GOGO | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GOGR | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GOAQ | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GRRE | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GROR | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GRGO | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GRGR | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-GRAQ | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-AQRE | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-AQOR | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-AQGO | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-AQGR | 20 (40 μL) | 200 μL |
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| AP1M1-RAB8A-20-AQAQ | 20 (40 μL) | 200 μL |
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RAB8A Gene Summary
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
Gene Name: RAB8A, Member RAS Oncogene Family
Chromosome: CHR19: 16222489 -16244445
Locus: 19p13.11
AP1M1 Gene Summary
The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Adaptor Related Protein Complex 1 Mu 1 Subunit
Chromosome: CHR19: 16308664 -16346156
Locus: 19p13.11
Gene Diseases
The AP1M1 RAB8A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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