ANTXR1-APLF Fusion FISH Probe
The ANTXR1-APLF Fusion FISH Probe is used to confirm a fusion of the ANTXR1 and APLF genes. The fusion of the ANTXR1 and APLF genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANTXR1-APLF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-RERE | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-REOR | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-REGO | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-REGR | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-REAQ | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-ORRE | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-OROR | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-ORGO | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GORE | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GOOR | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GOGO | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GOGR | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GRRE | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GROR | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GRGO | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GRGR | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-AQRE | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-AQOR | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-AQGO | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-AQGR | 20 (40 μL) | 200 μL |
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| ANTXR1-APLF-20-AQAQ | 20 (40 μL) | 200 μL |
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ANTXR1 Gene Summary
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Name: Anthrax Toxin Receptor 1
Chromosome: CHR2: 69240275 -69476459
Locus: 2p13.3
APLF Gene Summary
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008]
Gene Name: Aprataxin And PNKP Like Factor
Chromosome: CHR2: 68694690 -68807294
Locus: 2p13.3
Gene Diseases
The ANTXR1 APLF Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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