ANKRD26-MCM10 Fusion FISH Probe
The ANKRD26-MCM10 Fusion FISH Probe is used to confirm a fusion of the ANKRD26 and MCM10 genes. The fusion of the ANKRD26 and MCM10 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANKRD26-MCM10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-RERE | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-REOR | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-REGO | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-REGR | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-REAQ | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-ORRE | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-OROR | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-ORGO | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GORE | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GOOR | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GOGO | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GOGR | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GRRE | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GROR | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GRGO | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GRGR | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-AQRE | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-AQOR | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-AQGO | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-AQGR | 20 (40 μL) | 200 μL |
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| ANKRD26-MCM10-20-AQAQ | 20 (40 μL) | 200 μL |
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ANKRD26 Gene Summary
This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Ankyrin Repeat Domain 26
Chromosome: CHR10: 27293044 -27389427
Locus: 10p12.1
MCM10 Gene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Minichromosome Maintenance 10 Replication Initiation Factor
Chromosome: CHR10: 13203553 -13253104
Locus: 10p13
Gene Diseases
The ANKRD26 MCM10 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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