ANKRD12-PTPRM Fusion FISH Probe
The ANKRD12-PTPRM Fusion FISH Probe is used to confirm a fusion of the ANKRD12 and PTPRM genes. The fusion of the ANKRD12 and PTPRM genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANKRD12-PTPRM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-RERE | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-REOR | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-REGO | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-REGR | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-REAQ | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-ORRE | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-OROR | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-ORGO | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GORE | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GOOR | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GOGO | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GOGR | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GRRE | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GROR | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GRGO | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GRGR | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-AQRE | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-AQOR | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-AQGO | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-AQGR | 20 (40 μL) | 200 μL |
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| ANKRD12-PTPRM-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRM Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type M
Chromosome: CHR18: 7567313 -8406859
Locus: 18p11.23
ANKRD12 Gene Summary
This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Gene Name: Ankyrin Repeat Domain 12
Chromosome: CHR18: 9136750 -9285983
Locus: 18p11.22
Gene Diseases
The ANKRD12 PTPRM Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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