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ANKRD12-EPB41L3 Fusion FISH Probe

The ANKRD12-EPB41L3 Fusion FISH Probe is used to confirm a fusion of the ANKRD12 and EPB41L3 genes. The fusion of the ANKRD12 and EPB41L3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ANKRD12-EPB41L3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-RERE 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-REOR 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-REGO 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-REGR 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-REAQ 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-ORRE 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-OROR 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-ORGO 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-ORAQ 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GORE 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GOOR 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GOGO 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GOGR 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GOAQ 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GRRE 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GROR 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GRGO 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GRGR 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-GRAQ 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-AQRE 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-AQOR 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-AQGO 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-AQGR 20 (40 μL) 200 μL
ANKRD12-EPB41L3-20-AQAQ 20 (40 μL) 200 μL

EPB41L3 Gene Summary

The Erythrocyte Membrane Protein Band 4.1 Like 3 (EPB41L3) gene is located on chr18 :5392387-5543986 at 18p11.31.

Gene Name: Erythrocyte Membrane Protein Band 4.1 Like 3

Chromosome: CHR18: 5392387 -5543986

Locus: 18p11.31

ANKRD12 Gene Summary

This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Gene Name: Ankyrin Repeat Domain 12

Chromosome: CHR18: 9136750 -9285983

Locus: 18p11.22

Gene Diseases

The ANKRD12 EPB41L3 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Chromosomal aberrations in chordoid meningioma—An analysis

Chordoid meningiomas are rare tumors that have been found to have deletions such as 22q, 18p, 14q, and 1p. Although the deletions are known, their correlation to their clinical findings is not as established. FISH analysis was used with a variety of our probes to see which deletion(s) each case under study had. It was found that any recurrence of chordoid meningioma had all four chromosome loci deleted.