ANKRD11-FANCA Fusion FISH Probe
The ANKRD11-FANCA Fusion FISH Probe is used to confirm a fusion of the ANKRD11 and FANCA genes. The fusion of the ANKRD11 and FANCA genes has been associated with Lung Adenocarcinoma, Stomach Adenocarcinoma, Stomach Adenocarcinoma, and Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANKRD11-FANCA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-RERE | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-REOR | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-REGO | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-REGR | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-REAQ | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-ORRE | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-OROR | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-ORGO | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GORE | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GOOR | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GOGO | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GOGR | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GRRE | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GROR | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GRGO | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GRGR | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-AQRE | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-AQOR | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-AQGO | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-AQGR | 20 (40 μL) | 200 μL |
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| ANKRD11-FANCA-20-AQAQ | 20 (40 μL) | 200 μL |
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FANCA Gene Summary
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008]
Gene Name: Fanconi Anemia Complementation Group A
Chromosome: CHR16: 89803958 -89883065
Locus: 16q24.3
ANKRD11 Gene Summary
This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012]
Gene Name: Ankyrin Repeat Domain 11
Chromosome: CHR16: 89334034 -89556969
Locus: 16q24.3
Gene Diseases
The ANKRD11 FANCA Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Stomach Adenocarcinoma |
| Stomach Adenocarcinoma |
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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