ANKLE2-NCOR2 Fusion FISH Probe
The ANKLE2-NCOR2 Fusion FISH Probe is used to confirm a fusion of the ANKLE2 and NCOR2 genes. The fusion of the ANKLE2 and NCOR2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANKLE2-NCOR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-RERE | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-REOR | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-REGO | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-REGR | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-REAQ | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-ORRE | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-OROR | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-ORGO | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GORE | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GOOR | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GOGO | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GOGR | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GRRE | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GROR | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GRGO | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GRGR | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-AQRE | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-AQOR | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-AQGO | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-AQGR | 20 (40 μL) | 200 μL |
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| ANKLE2-NCOR2-20-AQAQ | 20 (40 μL) | 200 μL |
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NCOR2 Gene Summary
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Gene Name: Nuclear Receptor Corepressor 2
Chromosome: CHR12: 124808956 -125052010
Locus: 12q24.31
ANKLE2 Gene Summary
This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]
Gene Name: Ankyrin Repeat And LEM Domain Containing 2
Chromosome: CHR12: 133302253 -133338451
Locus: 12q24.33
Gene Diseases
The ANKLE2 NCOR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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