ANKH-MXD3 Fusion FISH Probe
The ANKH-MXD3 Fusion FISH Probe is used to confirm a fusion of the ANKH and MXD3 genes. The fusion of the ANKH and MXD3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANKH-MXD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-RERE | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-REOR | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-REGO | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-REGR | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-REAQ | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-ORRE | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-OROR | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-ORGO | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GORE | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GOOR | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GOGO | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GOGR | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GRRE | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GROR | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GRGO | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GRGR | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-AQRE | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-AQOR | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-AQGO | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-AQGR | 20 (40 μL) | 200 μL |
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| ANKH-MXD3-20-AQAQ | 20 (40 μL) | 200 μL |
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ANKH Gene Summary
This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008]
Gene Name: ANKH Inorganic Pyrophosphate Transport Regulator
Chromosome: CHR5: 14704908 -14871887
Locus: 5p15.2
MXD3 Gene Summary
This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Gene Name: MAX Dimerization Protein 3
Chromosome: CHR5: 176732500 -176739292
Locus: 5q35.3
Gene Diseases
The ANKH MXD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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