ANK3-TMPRSS15 Fusion FISH Probe
The ANK3-TMPRSS15 Fusion FISH Probe is used to confirm a fusion of the ANK3 and TMPRSS15 genes. The fusion of the ANK3 and TMPRSS15 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANK3-TMPRSS15-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-RERE | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-REOR | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-REGO | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-REGR | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-REAQ | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-ORRE | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-OROR | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-ORGO | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GORE | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GOOR | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GOGO | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GOGR | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GRRE | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GROR | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GRGO | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GRGR | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-AQRE | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-AQOR | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-AQGO | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-AQGR | 20 (40 μL) | 200 μL |
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| ANK3-TMPRSS15-20-AQAQ | 20 (40 μL) | 200 μL |
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ANK3 Gene Summary
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Ankyrin 3
Chromosome: CHR10: 61786055 -62493284
Locus: 10q21.2
TMPRSS15 Gene Summary
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane Protease, Serine 15
Chromosome: CHR21: 19641432 -19775970
Locus: 21q21.1
Gene Diseases
The ANK3 TMPRSS15 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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