ANK3-SP2 Fusion FISH Probe
The ANK3-SP2 Fusion FISH Probe is used to confirm a fusion of the ANK3 and SP2 genes. The fusion of the ANK3 and SP2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANK3-SP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-RERE | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-REOR | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-REGO | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-REGR | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-REAQ | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-ORRE | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-OROR | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-ORGO | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GORE | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GOOR | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GOGO | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GOGR | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GRRE | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GROR | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GRGO | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GRGR | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-AQRE | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-AQOR | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-AQGO | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-AQGR | 20 (40 μL) | 200 μL |
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| ANK3-SP2-20-AQAQ | 20 (40 μL) | 200 μL |
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ANK3 Gene Summary
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Ankyrin 3
Chromosome: CHR10: 61786055 -62493284
Locus: 10q21.2
SP2 Gene Summary
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
Gene Name: Sp2 Transcription Factor
Chromosome: CHR17: 45973515 -46006323
Locus: 17q21.32
Gene Diseases
The ANK3 SP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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