ANK3-CHN2 Fusion FISH Probe
The ANK3-CHN2 Fusion FISH Probe is used to confirm a fusion of the ANK3 and CHN2 genes. The fusion of the ANK3 and CHN2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANK3-CHN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-RERE | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-REOR | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-REGO | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-REGR | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-REAQ | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-ORRE | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-OROR | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-ORGO | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GORE | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GOOR | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GOGO | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GOGR | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GRRE | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GROR | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GRGO | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GRGR | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-AQRE | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-AQOR | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-AQGO | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-AQGR | 20 (40 μL) | 200 μL |
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| ANK3-CHN2-20-AQAQ | 20 (40 μL) | 200 μL |
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ANK3 Gene Summary
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Ankyrin 3
Chromosome: CHR10: 61786055 -62493284
Locus: 10q21.2
CHN2 Gene Summary
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: Chimerin 2
Chromosome: CHR7: 29234120 -29553944
Locus: 7p14.3
Gene Diseases
The ANK3 CHN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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