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ANK3-CDK1 Fusion FISH Probe

The ANK3-CDK1 Fusion FISH Probe is used to confirm a fusion of the ANK3 and CDK1 genes. The fusion of the ANK3 and CDK1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ANK3-CDK1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ANK3-CDK1-20-RERE 20 (40 μL) 200 μL
ANK3-CDK1-20-REOR 20 (40 μL) 200 μL
ANK3-CDK1-20-REGO 20 (40 μL) 200 μL
ANK3-CDK1-20-REGR 20 (40 μL) 200 μL
ANK3-CDK1-20-REAQ 20 (40 μL) 200 μL
ANK3-CDK1-20-ORRE 20 (40 μL) 200 μL
ANK3-CDK1-20-OROR 20 (40 μL) 200 μL
ANK3-CDK1-20-ORGO 20 (40 μL) 200 μL
ANK3-CDK1-20-ORAQ 20 (40 μL) 200 μL
ANK3-CDK1-20-GORE 20 (40 μL) 200 μL
ANK3-CDK1-20-GOOR 20 (40 μL) 200 μL
ANK3-CDK1-20-GOGO 20 (40 μL) 200 μL
ANK3-CDK1-20-GOGR 20 (40 μL) 200 μL
ANK3-CDK1-20-GOAQ 20 (40 μL) 200 μL
ANK3-CDK1-20-GRRE 20 (40 μL) 200 μL
ANK3-CDK1-20-GROR 20 (40 μL) 200 μL
ANK3-CDK1-20-GRGO 20 (40 μL) 200 μL
ANK3-CDK1-20-GRGR 20 (40 μL) 200 μL
ANK3-CDK1-20-GRAQ 20 (40 μL) 200 μL
ANK3-CDK1-20-AQRE 20 (40 μL) 200 μL
ANK3-CDK1-20-AQOR 20 (40 μL) 200 μL
ANK3-CDK1-20-AQGO 20 (40 μL) 200 μL
ANK3-CDK1-20-AQGR 20 (40 μL) 200 μL
ANK3-CDK1-20-AQAQ 20 (40 μL) 200 μL

ANK3 Gene Summary

Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Gene Name: Ankyrin 3

Chromosome: CHR10: 61786055 -62493284

Locus: 10q21.2

CDK1 Gene Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Name: Cyclin Dependent Kinase 1

Chromosome: CHR10: 62538211 -62554610

Locus: 10q21.2

Gene Diseases

The ANK3 CDK1 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.