ANK3-CDK1 Fusion FISH Probe
The ANK3-CDK1 Fusion FISH Probe is used to confirm a fusion of the ANK3 and CDK1 genes. The fusion of the ANK3 and CDK1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ANK3-CDK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ANK3-CDK1-20-AQAQ | 20 (40 μL) | 200 μL |
|
ANK3 Gene Summary
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Ankyrin 3
Chromosome: CHR10: 61786055 -62493284
Locus: 10q21.2
CDK1 Gene Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: Cyclin Dependent Kinase 1
Chromosome: CHR10: 62538211 -62554610
Locus: 10q21.2
Gene Diseases
The ANK3 CDK1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|