ANK2-ARHGAP31 Fusion FISH Probe
The ANK2-ARHGAP31 Fusion FISH Probe is used to confirm a fusion of the ANK2 and ARHGAP31 genes. The fusion of the ANK2 and ARHGAP31 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANK2-ARHGAP31-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-RERE | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-REOR | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-REGO | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-REGR | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-REAQ | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-ORRE | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-OROR | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-ORGO | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GORE | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GOOR | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GOGO | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GOGR | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GRRE | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GROR | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GRGO | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GRGR | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-AQRE | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-AQOR | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-AQGO | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-AQGR | 20 (40 μL) | 200 μL |
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| ANK2-ARHGAP31-20-AQAQ | 20 (40 μL) | 200 μL |
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ANK2 Gene Summary
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
Gene Name: Ankyrin 2
Chromosome: CHR4: 113739238 -114304896
Locus: 4q25-q26
ARHGAP31 Gene Summary
This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008]
Gene Name: Rho GTPase Activating Protein 31
Chromosome: CHR3: 119013219 -119138323
Locus: 3q13.32-q13.33
Gene Diseases
The ANK2 ARHGAP31 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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