ANK2-ALPK1 Fusion FISH Probe
The ANK2-ALPK1 Fusion FISH Probe is used to confirm a fusion of the ANK2 and ALPK1 genes. The fusion of the ANK2 and ALPK1 genes has been associated with Lung Adenocarcinoma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANK2-ALPK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-RERE | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-REOR | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-REGO | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-REGR | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-REAQ | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-ORRE | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-OROR | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-ORGO | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GORE | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GOOR | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GOGO | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GOGR | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GRRE | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GROR | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GRGO | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GRGR | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-AQRE | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-AQOR | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-AQGO | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-AQGR | 20 (40 μL) | 200 μL |
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| ANK2-ALPK1-20-AQAQ | 20 (40 μL) | 200 μL |
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ANK2 Gene Summary
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
Gene Name: Ankyrin 2
Chromosome: CHR4: 113739238 -114304896
Locus: 4q25-q26
ALPK1 Gene Summary
This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordination defects (PMID: 21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Alpha Kinase 1
Chromosome: CHR4: 113218498 -113363764
Locus: 4q25
Gene Diseases
The ANK2 ALPK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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