ANGPT1-TNFRSF11B Fusion FISH Probe
The ANGPT1-TNFRSF11B Fusion FISH Probe is used to confirm a fusion of the ANGPT1 and TNFRSF11B genes. The fusion of the ANGPT1 and TNFRSF11B genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANGPT1-TNFRSF11B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-RERE | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-REOR | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-REGO | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-REGR | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-REAQ | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-ORRE | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-OROR | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-ORGO | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GORE | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GOOR | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GOGO | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GOGR | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GRRE | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GROR | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GRGO | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GRGR | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-AQRE | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-AQOR | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-AQGO | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-AQGR | 20 (40 μL) | 200 μL |
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| ANGPT1-TNFRSF11B-20-AQAQ | 20 (40 μL) | 200 μL |
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ANGPT1 Gene Summary
This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Gene Name: Angiopoietin 1
Chromosome: CHR8: 108261709 -108510254
Locus: 8q23.1
TNFRSF11B Gene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: TNF Receptor Superfamily Member 11b
Chromosome: CHR8: 119935795 -119964383
Locus: 8q24.12
Gene Diseases
The ANGPT1 TNFRSF11B Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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