ANAPC5-KDM2B Fusion FISH Probe
The ANAPC5-KDM2B Fusion FISH Probe is used to confirm a fusion of the ANAPC5 and KDM2B genes. The fusion of the ANAPC5 and KDM2B genes has been associated with Stomach Adenocarcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANAPC5-KDM2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-RERE | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-REOR | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-REGO | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-REGR | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-REAQ | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-ORRE | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-OROR | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-ORGO | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GORE | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GOOR | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GOGO | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GOGR | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GRRE | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GROR | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GRGO | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GRGR | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-AQRE | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-AQOR | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-AQGO | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-AQGR | 20 (40 μL) | 200 μL |
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| ANAPC5-KDM2B-20-AQAQ | 20 (40 μL) | 200 μL |
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ANAPC5 Gene Summary
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
Gene Name: Anaphase Promoting Complex Subunit 5
Chromosome: CHR12: 121746047 -121792012
Locus: 12q24.31
KDM2B Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Lysine Demethylase 2B
Chromosome: CHR12: 121866899 -122018920
Locus: 12q24.31
Gene Diseases
The ANAPC5 KDM2B Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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