ANAPC5-ADAM15 Fusion FISH Probe
The ANAPC5-ADAM15 Fusion FISH Probe is used to confirm a fusion of the ANAPC5 and ADAM15 genes. The fusion of the ANAPC5 and ADAM15 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANAPC5-ADAM15-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-RERE | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-REOR | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-REGO | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-REGR | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-REAQ | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-ORRE | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-OROR | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-ORGO | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GORE | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GOOR | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GOGO | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GOGR | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GRRE | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GROR | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GRGO | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GRGR | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-AQRE | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-AQOR | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-AQGO | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-AQGR | 20 (40 μL) | 200 μL |
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| ANAPC5-ADAM15-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM15 Gene Summary
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: ADAM Metallopeptidase Domain 15
Chromosome: CHR1: 155023761 -155035252
Locus: 1q21.3
ANAPC5 Gene Summary
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
Gene Name: Anaphase Promoting Complex Subunit 5
Chromosome: CHR12: 121746047 -121792012
Locus: 12q24.31
Gene Diseases
The ANAPC5 ADAM15 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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