AMMECR1-PLA2G12B Fusion FISH Probe
The AMMECR1-PLA2G12B Fusion FISH Probe is used to confirm a fusion of the AMMECR1 and PLA2G12B genes. The fusion of the AMMECR1 and PLA2G12B genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AMMECR1-PLA2G12B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-RERE | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-REOR | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-REGO | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-REGR | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-REAQ | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-ORRE | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-OROR | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-ORGO | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-ORAQ | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GORE | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GOOR | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GOGO | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GOGR | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GOAQ | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GRRE | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GROR | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GRGO | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GRGR | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-GRAQ | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-AQRE | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-AQOR | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-AQGO | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-AQGR | 20 (40 μL) | 200 μL |
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| AMMECR1-PLA2G12B-20-AQAQ | 20 (40 μL) | 200 μL |
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AMMECR1 Gene Summary
The exact function of this gene is not known, however, submicroscopic deletion of the X chromosome including this gene, COL4A5, and FACL4 genes, result in a contiguous gene deletion syndrome, the AMME complex (Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Name: Alport Syndrome, Mental Retardation, Midface Hypoplasia And Elliptocytosis Chromosomal Region Gene 1
Chromosome: CHRX: 109437413 -109683461
Locus: Xq23
PLA2G12B Gene Summary
The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: Phospholipase A2 Group XIIB
Chromosome: CHR10: 74694937 -74714510
Locus: 10q22.1
Gene Diseases
The AMMECR1 PLA2G12B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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