AMFR-ITGAM Fusion FISH Probe
The AMFR-ITGAM Fusion FISH Probe is used to confirm a fusion of the AMFR and ITGAM genes. The fusion of the AMFR and ITGAM genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AMFR-ITGAM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-RERE | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-REOR | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-REGO | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-REGR | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-REAQ | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-ORRE | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-OROR | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-ORGO | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-ORAQ | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GORE | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GOOR | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GOGO | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GOGR | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GOAQ | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GRRE | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GROR | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GRGO | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GRGR | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-GRAQ | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-AQRE | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-AQOR | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-AQGO | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-AQGR | 20 (40 μL) | 200 μL |
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| AMFR-ITGAM-20-AQAQ | 20 (40 μL) | 200 μL |
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AMFR Gene Summary
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]
Gene Name: Autocrine Motility Factor Receptor
Chromosome: CHR16: 56395363 -56459444
Locus: 16q13
ITGAM Gene Summary
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: Integrin Subunit Alpha M
Chromosome: CHR16: 31271287 -31344213
Locus: 16p11.2
Gene Diseases
The AMFR ITGAM Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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