AMBRA1-CKAP5 Fusion FISH Probe
The AMBRA1-CKAP5 Fusion FISH Probe is used to confirm a fusion of the AMBRA1 and CKAP5 genes. The fusion of the AMBRA1 and CKAP5 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AMBRA1-CKAP5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-RERE | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-REOR | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-REGO | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-REGR | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-REAQ | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-ORRE | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-OROR | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-ORGO | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-ORAQ | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GORE | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GOOR | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GOGO | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GOGR | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GOAQ | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GRRE | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GROR | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GRGO | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GRGR | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-GRAQ | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-AQRE | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-AQOR | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-AQGO | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-AQGR | 20 (40 μL) | 200 μL |
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| AMBRA1-CKAP5-20-AQAQ | 20 (40 μL) | 200 μL |
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CKAP5 Gene Summary
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Cytoskeleton Associated Protein 5
Chromosome: CHR11: 46765083 -46867859
Locus: 11p11.2
AMBRA1 Gene Summary
The Autophagy And Beclin 1 Regulator 1 (AMBRA1) gene is located on chr11 :46417963-46612914 at 11p11.2.
Gene Name: Autophagy And Beclin 1 Regulator 1
Chromosome: CHR11: 46417963 -46612914
Locus: 11p11.2
Gene Diseases
The AMBRA1 CKAP5 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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