AMACR-NDUFAF2 Fusion FISH Probe
The AMACR-NDUFAF2 Fusion FISH Probe is used to confirm a fusion of the AMACR and NDUFAF2 genes. The fusion of the AMACR and NDUFAF2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AMACR-NDUFAF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-RERE | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-REOR | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-REGO | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-REGR | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-REAQ | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-ORRE | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-OROR | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-ORGO | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GORE | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GOOR | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GOGO | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GOGR | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GRRE | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GROR | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GRGO | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GRGR | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-AQRE | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-AQOR | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-AQGO | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-AQGR | 20 (40 μL) | 200 μL |
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| AMACR-NDUFAF2-20-AQAQ | 20 (40 μL) | 200 μL |
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AMACR Gene Summary
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Gene Name: Alpha-methylacyl-CoA Racemase
Chromosome: CHR5: 33987090 -34008220
Locus: 5p13.2
NDUFAF2 Gene Summary
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency. [provided by RefSeq, Jul 2008]
Gene Name: NADH:ubiquinone Oxidoreductase Complex Assembly Factor 2
Chromosome: CHR5: 60240955 -60448864
Locus: 5q12.1
Gene Diseases
The AMACR NDUFAF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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