ALX4-LMX1A Fusion FISH Probe
The ALX4-LMX1A Fusion FISH Probe is used to confirm a fusion of the ALX4 and LMX1A genes. The fusion of the ALX4 and LMX1A genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ALX4-LMX1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-RERE | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-REOR | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-REGO | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-REGR | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-REAQ | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-ORRE | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-OROR | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-ORGO | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GORE | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GOOR | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GOGO | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GOGR | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GRRE | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GROR | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GRGO | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GRGR | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-AQRE | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-AQOR | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-AQGO | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-AQGR | 20 (40 μL) | 200 μL |
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| ALX4-LMX1A-20-AQAQ | 20 (40 μL) | 200 μL |
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LMX1A Gene Summary
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Name: LIM Homeobox Transcription Factor 1 Alpha
Chromosome: CHR1: 165171103 -165325952
Locus: 1q23.3
ALX4 Gene Summary
This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, cognitive disability, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009]
Gene Name: ALX Homeobox 4
Chromosome: CHR11: 44282277 -44331716
Locus: 11p11.2
Gene Diseases
The ALX4 LMX1A Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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