ALPL-EIF4G3 Fusion FISH Probe
The ALPL-EIF4G3 Fusion FISH Probe is used to confirm a fusion of the ALPL and EIF4G3 genes. The fusion of the ALPL and EIF4G3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ALPL-EIF4G3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-RERE | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-REOR | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-REGO | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-REGR | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-REAQ | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-ORRE | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-OROR | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-ORGO | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GORE | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GOOR | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GOGO | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GOGR | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GRRE | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GROR | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GRGO | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GRGR | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-AQRE | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-AQOR | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-AQGO | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-AQGR | 20 (40 μL) | 200 μL |
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| ALPL-EIF4G3-20-AQAQ | 20 (40 μL) | 200 μL |
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ALPL Gene Summary
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Gene Name: Alkaline Phosphatase, Liver/bone/kidney
Chromosome: CHR1: 21835857 -21904905
Locus: 1p36.12
EIF4G3 Gene Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Gene Name: Eukaryotic Translation Initiation Factor 4 Gamma 3
Chromosome: CHR1: 21132784 -21503381
Locus: 1p36.12
Gene Diseases
The ALPL EIF4G3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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