ALKBH3-ANO3 Fusion FISH Probe
The ALKBH3-ANO3 Fusion FISH Probe is used to confirm a fusion of the ALKBH3 and ANO3 genes. The fusion of the ALKBH3 and ANO3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ALKBH3-ANO3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-RERE | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-REOR | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-REGO | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-REGR | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-REAQ | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-ORRE | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-OROR | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-ORGO | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GORE | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GOOR | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GOGO | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GOGR | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GRRE | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GROR | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GRGO | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GRGR | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-AQRE | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-AQOR | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-AQGO | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-AQGR | 20 (40 μL) | 200 μL |
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| ALKBH3-ANO3-20-AQAQ | 20 (40 μL) | 200 μL |
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ANO3 Gene Summary
The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Name: Anoctamin 3
Chromosome: CHR11: 26353677 -26684836
Locus: 11p14.3-p14.2
ALKBH3 Gene Summary
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Gene Name: AlkB Homolog 3, Alpha-ketoglutaratedependent Dioxygenase
Chromosome: CHR11: 43902356 -43941825
Locus: 11p11.2
Gene Diseases
The ALKBH3 ANO3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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