ALK-SCEL Fusion FISH Probe
The ALK-SCEL Fusion FISH Probe is used to confirm a fusion of the ALK and SCEL genes. The fusion of the ALK and SCEL genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ALK-SCEL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-RERE | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-REOR | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-REGO | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-REGR | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-REAQ | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-ORRE | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-OROR | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-ORGO | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-ORAQ | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GORE | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GOOR | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GOGO | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GOGR | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GOAQ | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GRRE | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GROR | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GRGO | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GRGR | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-GRAQ | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-AQRE | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-AQOR | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-AQGO | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-AQGR | 20 (40 μL) | 200 μL |
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| ALK-SCEL-20-AQAQ | 20 (40 μL) | 200 μL |
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ALK Gene Summary
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Gene Name: ALK Receptor Tyrosine Kinase
Chromosome: CHR2: 29415639 -30144477
Locus: 2p23.2-p23.1
SCEL Gene Summary
The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Sciellin
Chromosome: CHR13: 78109808 -78219398
Locus: 13q22.3
Gene Diseases
The ALK SCEL Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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