ALDOA-NDUFV1 Fusion FISH Probe
The ALDOA-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the ALDOA and NDUFV1 genes. The fusion of the ALDOA and NDUFV1 genes has been associated with Breast Invasive Carcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ALDOA-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| ALDOA-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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ALDOA Gene Summary
This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]
Gene Name: Aldolase, Fructose-bisphosphate A
Chromosome: CHR16: 30064410 -30081741
Locus: 16p11.2
NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
Gene Diseases
The ALDOA NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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