ALDH5A1-MAP3K5 Fusion FISH Probe
The ALDH5A1-MAP3K5 Fusion FISH Probe is used to confirm a fusion of the ALDH5A1 and MAP3K5 genes. The fusion of the ALDH5A1 and MAP3K5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ALDH5A1-MAP3K5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-RERE | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-REOR | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-REGO | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-REGR | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-REAQ | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-ORRE | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-OROR | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-ORGO | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-ORAQ | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GORE | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GOOR | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GOGO | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GOGR | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GOAQ | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GRRE | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GROR | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GRGO | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GRGR | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-GRAQ | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-AQRE | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-AQOR | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-AQGO | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-AQGR | 20 (40 μL) | 200 μL |
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| ALDH5A1-MAP3K5-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K5 Gene Summary
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 5
Chromosome: CHR6: 136878186 -137113656
Locus: 6q23.3
ALDH5A1 Gene Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Aldehyde Dehydrogenase 5 Family Member A1
Chromosome: CHR6: 24495196 -24537435
Locus: 6p22.3
Gene Diseases
The ALDH5A1 MAP3K5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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