ALDH2-LRBA Fusion FISH Probe
The ALDH2-LRBA Fusion FISH Probe is used to confirm a fusion of the ALDH2 and LRBA genes. The fusion of the ALDH2 and LRBA genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ALDH2-LRBA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-RERE | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-REOR | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-REGO | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-REGR | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-REAQ | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-ORRE | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-OROR | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-ORGO | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-ORAQ | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GORE | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GOOR | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GOGO | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GOGR | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GOAQ | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GRRE | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GROR | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GRGO | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GRGR | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-GRAQ | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-AQRE | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-AQOR | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-AQGO | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-AQGR | 20 (40 μL) | 200 μL |
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| ALDH2-LRBA-20-AQAQ | 20 (40 μL) | 200 μL |
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ALDH2 Gene Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]
Gene Name: Aldehyde Dehydrogenase 2 Family (mitochondrial)
Chromosome: CHR12: 112204690 -112247789
Locus: 12q24.12
LRBA Gene Summary
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: LPS Responsive Beige-like Anchor Protein
Chromosome: CHR4: 151185810 -151936649
Locus: 4q31.3
Gene Diseases
The ALDH2 LRBA Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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