ALDH1A1-TYK2 Fusion FISH Probe
The ALDH1A1-TYK2 Fusion FISH Probe is used to confirm a fusion of the ALDH1A1 and TYK2 genes. The fusion of the ALDH1A1 and TYK2 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ALDH1A1-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| ALDH1A1-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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ALDH1A1 Gene Summary
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
Gene Name: Aldehyde Dehydrogenase 1 Family Member A1
Chromosome: CHR9: 75515577 -75568233
Locus: 9q21.13
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The ALDH1A1 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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