ALAS1-PARP3 Fusion FISH Probe
The ALAS1-PARP3 Fusion FISH Probe is used to confirm a fusion of the ALAS1 and PARP3 genes. The fusion of the ALAS1 and PARP3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ALAS1-PARP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-RERE | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-REOR | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-REGO | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-REGR | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-REAQ | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-ORRE | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-OROR | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-ORGO | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GORE | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GOOR | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GOGO | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GOGR | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GRRE | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GROR | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GRGO | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GRGR | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-AQRE | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-AQOR | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-AQGO | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-AQGR | 20 (40 μL) | 200 μL |
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| ALAS1-PARP3-20-AQAQ | 20 (40 μL) | 200 μL |
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ALAS1 Gene Summary
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Gene Name: 5'-aminolevulinate Synthase 1
Chromosome: CHR3: 52232115 -52248343
Locus: 3p21.2
PARP3 Gene Summary
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Poly(ADP-ribose) Polymerase Family Member 3
Chromosome: CHR3: 51976360 -51982883
Locus: 3p21.2
Gene Diseases
The ALAS1 PARP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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