AKT3-PTPRR Fusion FISH Probe
The AKT3-PTPRR Fusion FISH Probe is used to confirm a fusion of the AKT3 and PTPRR genes. The fusion of the AKT3 and PTPRR genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AKT3-PTPRR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-RERE | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-REOR | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-REGO | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-REGR | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-REAQ | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-ORRE | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-OROR | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-ORGO | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-ORAQ | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GORE | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GOOR | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GOGO | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GOGR | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GOAQ | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GRRE | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GROR | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GRGO | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GRGR | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-GRAQ | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-AQRE | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-AQOR | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-AQGO | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-AQGR | 20 (40 μL) | 200 μL |
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| AKT3-PTPRR-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRR Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type R
Chromosome: CHR12: 71031852 -71314584
Locus: 12q15
AKT3 Gene Summary
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: AKT Serine/threonine Kinase 3
Chromosome: CHR1: 243651534 -244006584
Locus: 1q43-q44
Gene Diseases
The AKT3 PTPRR Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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