AKT3-PPP2R2A Fusion FISH Probe
The AKT3-PPP2R2A Fusion FISH Probe is used to confirm a fusion of the AKT3 and PPP2R2A genes. The fusion of the AKT3 and PPP2R2A genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AKT3-PPP2R2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-RERE | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-REOR | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-REGO | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-REGR | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-REAQ | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-ORRE | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-OROR | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-ORGO | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GORE | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GOOR | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GOGO | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GOGR | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GRRE | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GROR | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GRGO | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GRGR | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-AQRE | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-AQOR | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-AQGO | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-AQGR | 20 (40 μL) | 200 μL |
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| AKT3-PPP2R2A-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP2R2A Gene Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Gene Name: Protein Phosphatase 2 Regulatory Subunit Balpha
Chromosome: CHR8: 26149006 -26230195
Locus: 8p21.2
AKT3 Gene Summary
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: AKT Serine/threonine Kinase 3
Chromosome: CHR1: 243651534 -244006584
Locus: 1q43-q44
Gene Diseases
The AKT3 PPP2R2A Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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