AKT2-UPF1 Fusion FISH Probe
The AKT2-UPF1 Fusion FISH Probe is used to confirm a fusion of the AKT2 and UPF1 genes. The fusion of the AKT2 and UPF1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AKT2-UPF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-RERE | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-REOR | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-REGO | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-REGR | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-REAQ | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-ORRE | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-OROR | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-ORGO | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GORE | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GOOR | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GOGO | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GOGR | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GRRE | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GROR | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GRGO | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GRGR | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-AQRE | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-AQOR | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-AQGO | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-AQGR | 20 (40 μL) | 200 μL |
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| AKT2-UPF1-20-AQAQ | 20 (40 μL) | 200 μL |
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AKT2 Gene Summary
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
Gene Name: AKT Serine/threonine Kinase 2
Chromosome: CHR19: 40736223 -40791302
Locus: 19q13.2
UPF1 Gene Summary
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: UPF1, RNA Helicase And ATPase
Chromosome: CHR19: 18942743 -18979039
Locus: 19p13.11
Gene Diseases
The AKT2 UPF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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