AKT2-ELK3 Fusion FISH Probe
The AKT2-ELK3 Fusion FISH Probe is used to confirm a fusion of the AKT2 and ELK3 genes. The fusion of the AKT2 and ELK3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AKT2-ELK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-RERE | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-REOR | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-REGO | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-REGR | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-REAQ | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-ORRE | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-OROR | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-ORGO | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GORE | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GOOR | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GOGO | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GOGR | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GRRE | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GROR | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GRGO | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GRGR | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-AQRE | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-AQOR | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-AQGO | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-AQGR | 20 (40 μL) | 200 μL |
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| AKT2-ELK3-20-AQAQ | 20 (40 μL) | 200 μL |
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AKT2 Gene Summary
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
Gene Name: AKT Serine/threonine Kinase 2
Chromosome: CHR19: 40736223 -40791302
Locus: 19q13.2
ELK3 Gene Summary
This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: ELK3, ETS Transcription Factor
Chromosome: CHR12: 96588206 -96661606
Locus: 12q23.1
Gene Diseases
The AKT2 ELK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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