AKT1-ANKS1A Fusion FISH Probe
The AKT1-ANKS1A Fusion FISH Probe is used to confirm a fusion of the AKT1 and ANKS1A genes. The fusion of the AKT1 and ANKS1A genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AKT1-ANKS1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-RERE | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-REOR | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-REGO | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-REGR | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-REAQ | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-ORRE | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-OROR | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-ORGO | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GORE | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GOOR | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GOGO | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GOGR | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GRRE | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GROR | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GRGO | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GRGR | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-AQRE | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-AQOR | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-AQGO | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-AQGR | 20 (40 μL) | 200 μL |
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| AKT1-ANKS1A-20-AQAQ | 20 (40 μL) | 200 μL |
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AKT1 Gene Summary
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Name: AKT Serine/threonine Kinase 1
Chromosome: CHR14: 105235686 -105262080
Locus: 14q32.33
ANKS1A Gene Summary
The Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1A (ANKS1A) gene is located on chr6 :34857037-35059190 at 6p21.31.
Gene Name: Ankyrin Repeat And Sterile Alpha Motif Domain Containing 1A
Chromosome: CHR6: 34857037 -35059190
Locus: 6p21.31
Gene Diseases
The AKT1 ANKS1A Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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