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AKAP8-CALR3 Fusion FISH Probe

The AKAP8-CALR3 Fusion FISH Probe is used to confirm a fusion of the AKAP8 and CALR3 genes. The fusion of the AKAP8 and CALR3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
AKAP8-CALR3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
AKAP8-CALR3-20-RERE 20 (40 μL) 200 μL
AKAP8-CALR3-20-REOR 20 (40 μL) 200 μL
AKAP8-CALR3-20-REGO 20 (40 μL) 200 μL
AKAP8-CALR3-20-REGR 20 (40 μL) 200 μL
AKAP8-CALR3-20-REAQ 20 (40 μL) 200 μL
AKAP8-CALR3-20-ORRE 20 (40 μL) 200 μL
AKAP8-CALR3-20-OROR 20 (40 μL) 200 μL
AKAP8-CALR3-20-ORGO 20 (40 μL) 200 μL
AKAP8-CALR3-20-ORAQ 20 (40 μL) 200 μL
AKAP8-CALR3-20-GORE 20 (40 μL) 200 μL
AKAP8-CALR3-20-GOOR 20 (40 μL) 200 μL
AKAP8-CALR3-20-GOGO 20 (40 μL) 200 μL
AKAP8-CALR3-20-GOGR 20 (40 μL) 200 μL
AKAP8-CALR3-20-GOAQ 20 (40 μL) 200 μL
AKAP8-CALR3-20-GRRE 20 (40 μL) 200 μL
AKAP8-CALR3-20-GROR 20 (40 μL) 200 μL
AKAP8-CALR3-20-GRGO 20 (40 μL) 200 μL
AKAP8-CALR3-20-GRGR 20 (40 μL) 200 μL
AKAP8-CALR3-20-GRAQ 20 (40 μL) 200 μL
AKAP8-CALR3-20-AQRE 20 (40 μL) 200 μL
AKAP8-CALR3-20-AQOR 20 (40 μL) 200 μL
AKAP8-CALR3-20-AQGO 20 (40 μL) 200 μL
AKAP8-CALR3-20-AQGR 20 (40 μL) 200 μL
AKAP8-CALR3-20-AQAQ 20 (40 μL) 200 μL

AKAP8 Gene Summary

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

Gene Name: A-kinase Anchoring Protein 8

Chromosome: CHR19: 15464331 -15490612

Locus: 19p13.12

CALR3 Gene Summary

The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]

Gene Name: Calreticulin 3

Chromosome: CHR19: 16589874 -16607003

Locus: 19p13.11

Gene Diseases

The AKAP8 CALR3 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.