AKAP13-NTRK3 Fusion FISH Probe
The AKAP13-NTRK3 Fusion FISH Probe is used to confirm a fusion of the AKAP13 and NTRK3 genes. The fusion of the AKAP13 and NTRK3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AKAP13-NTRK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-RERE | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-REOR | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-REGO | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-REGR | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-REAQ | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-ORRE | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-OROR | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-ORGO | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GORE | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GOOR | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GOGO | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GOGR | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GRRE | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GROR | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GRGO | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GRGR | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-AQRE | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-AQOR | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-AQGO | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-AQGR | 20 (40 μL) | 200 μL |
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| AKAP13-NTRK3-20-AQAQ | 20 (40 μL) | 200 μL |
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NTRK3 Gene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Name: Neurotrophic Receptor Tyrosine Kinase 3
Chromosome: CHR15: 88419987 -88799962
Locus: 15q25.3
AKAP13 Gene Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Gene Name: A-kinase Anchoring Protein 13
Chromosome: CHR15: 85923870 -86292586
Locus: 15q25.3
Gene Diseases
The AKAP13 NTRK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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