AKAP13-IGF1R Fusion FISH Probe
The AKAP13-IGF1R Fusion FISH Probe is used to confirm a fusion of the AKAP13 and IGF1R genes. The fusion of the AKAP13 and IGF1R genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AKAP13-IGF1R-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-RERE | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-REOR | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-REGO | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-REGR | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-REAQ | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-ORRE | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-OROR | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-ORGO | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-ORAQ | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GORE | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GOOR | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GOGO | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GOGR | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GOAQ | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GRRE | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GROR | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GRGO | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GRGR | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-GRAQ | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-AQRE | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-AQOR | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-AQGO | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-AQGR | 20 (40 μL) | 200 μL |
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| AKAP13-IGF1R-20-AQAQ | 20 (40 μL) | 200 μL |
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IGF1R Gene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Name: Insulin Like Growth Factor 1 Receptor
Chromosome: CHR15: 99192760 -99507759
Locus: 15q26.3
AKAP13 Gene Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Gene Name: A-kinase Anchoring Protein 13
Chromosome: CHR15: 85923870 -86292586
Locus: 15q25.3
Gene Diseases
The AKAP13 IGF1R Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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