AKAP13-CASC4 Fusion FISH Probe
The AKAP13-CASC4 Fusion FISH Probe is used to confirm a fusion of the AKAP13 and CASC4 genes. The fusion of the AKAP13 and CASC4 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| AKAP13-CASC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-RERE | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-REOR | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-REGO | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-REGR | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-OROR | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GORE | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GROR | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| AKAP13-CASC4-20-AQAQ | 20 (40 μL) | 200 μL |
|
AKAP13 Gene Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Gene Name: A-kinase Anchoring Protein 13
Chromosome: CHR15: 85923870 -86292586
Locus: 15q25.3
CASC4 Gene Summary
The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
Gene Name: Cancer Susceptibility 4
Chromosome: CHR15: 44580908 -44707959
Locus: 15q15.3
Gene Diseases
The AKAP13 CASC4 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|