AKAP1-GGA3 Fusion FISH Probe
The AKAP1-GGA3 Fusion FISH Probe is used to confirm a fusion of the AKAP1 and GGA3 genes. The fusion of the AKAP1 and GGA3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AKAP1-GGA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-RERE | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-REOR | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-REGO | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-REGR | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-REAQ | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-ORRE | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-OROR | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-ORGO | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GORE | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GOOR | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GOGO | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GOGR | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GRRE | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GROR | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GRGO | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GRGR | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-AQRE | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-AQOR | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-AQGO | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-AQGR | 20 (40 μL) | 200 μL |
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| AKAP1-GGA3-20-AQAQ | 20 (40 μL) | 200 μL |
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AKAP1 Gene Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Gene Name: A-kinase Anchoring Protein 1
Chromosome: CHR17: 55162552 -55198710
Locus: 17q22
GGA3 Gene Summary
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]
Gene Name: Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 3
Chromosome: CHR17: 73232693 -73258444
Locus: 17q25.1
Gene Diseases
The AKAP1 GGA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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