AK2-MKL1 Fusion FISH Probe
The AK2-MKL1 Fusion FISH Probe is used to confirm a fusion of the AK2 and MKL1 genes. The fusion of the AK2 and MKL1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AK2-MKL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-RERE | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-REOR | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-REGO | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-REGR | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-REAQ | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-ORRE | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-OROR | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-ORGO | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GORE | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GOOR | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GOGO | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GOGR | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GRRE | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GROR | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GRGO | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GRGR | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-AQRE | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-AQOR | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-AQGO | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-AQGR | 20 (40 μL) | 200 μL |
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| AK2-MKL1-20-AQAQ | 20 (40 μL) | 200 μL |
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AK2 Gene Summary
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]
Gene Name: Adenylate Kinase 2
Chromosome: CHR1: 33473540 -33502512
Locus: 1p35.1
MKL1 Gene Summary
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: Megakaryoblastic Leukemia (translocation) 1
Chromosome: CHR22: 40806291 -41032690
Locus: 22q13.1-q13.2
Gene Diseases
The AK2 MKL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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