AHNAK-TYK2 Fusion FISH Probe
The AHNAK-TYK2 Fusion FISH Probe is used to confirm a fusion of the AHNAK and TYK2 genes. The fusion of the AHNAK and TYK2 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AHNAK-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| AHNAK-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
AHNAK Gene Summary
The protein encoded by this gene is a large (700 kDa) structural scaffold protein consisting of a central domain with 128 aa repeats. The encoded protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac calcium channel regulation, and tumor metastasis. A much shorter variant encoding a 17 kDa isoform exists for this gene, and the shorter isoform initiates a feedback loop that regulates alternative splicing of this gene. [provided by RefSeq, Oct 2016]
Gene Name: AHNAK Nucleoprotein
Chromosome: CHR11: 62201015 -62314332
Locus: 11q12.3
Gene Diseases
The AHNAK TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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