AHNAK-STIP1 Fusion FISH Probe
The AHNAK-STIP1 Fusion FISH Probe is used to confirm a fusion of the AHNAK and STIP1 genes. The fusion of the AHNAK and STIP1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AHNAK-STIP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-RERE | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-REOR | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-REGO | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-REGR | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-REAQ | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-ORRE | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-OROR | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-ORGO | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GORE | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GOOR | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GOGO | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GOGR | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GRRE | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GROR | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GRGO | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GRGR | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-AQRE | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-AQOR | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-AQGO | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-AQGR | 20 (40 μL) | 200 μL |
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| AHNAK-STIP1-20-AQAQ | 20 (40 μL) | 200 μL |
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STIP1 Gene Summary
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Gene Name: Stress Induced Phosphoprotein 1
Chromosome: CHR11: 63953586 -63972020
Locus: 11q13.1
AHNAK Gene Summary
The protein encoded by this gene is a large (700 kDa) structural scaffold protein consisting of a central domain with 128 aa repeats. The encoded protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac calcium channel regulation, and tumor metastasis. A much shorter variant encoding a 17 kDa isoform exists for this gene, and the shorter isoform initiates a feedback loop that regulates alternative splicing of this gene. [provided by RefSeq, Oct 2016]
Gene Name: AHNAK Nucleoprotein
Chromosome: CHR11: 62201015 -62314332
Locus: 11q12.3
Gene Diseases
The AHNAK STIP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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