AHNAK-RPS6KA4 Fusion FISH Probe
The AHNAK-RPS6KA4 Fusion FISH Probe is used to confirm a fusion of the AHNAK and RPS6KA4 genes. The fusion of the AHNAK and RPS6KA4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AHNAK-RPS6KA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-RERE | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-REOR | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-REGO | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-REGR | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-REAQ | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-ORRE | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-OROR | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-ORGO | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GORE | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GOOR | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GOGO | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GOGR | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GRRE | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GROR | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GRGO | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GRGR | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-AQRE | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-AQOR | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-AQGO | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-AQGR | 20 (40 μL) | 200 μL |
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| AHNAK-RPS6KA4-20-AQAQ | 20 (40 μL) | 200 μL |
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RPS6KA4 Gene Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Gene Name: Ribosomal Protein S6 Kinase A4
Chromosome: CHR11: 64126624 -64139687
Locus: 11q13.1
AHNAK Gene Summary
The protein encoded by this gene is a large (700 kDa) structural scaffold protein consisting of a central domain with 128 aa repeats. The encoded protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac calcium channel regulation, and tumor metastasis. A much shorter variant encoding a 17 kDa isoform exists for this gene, and the shorter isoform initiates a feedback loop that regulates alternative splicing of this gene. [provided by RefSeq, Oct 2016]
Gene Name: AHNAK Nucleoprotein
Chromosome: CHR11: 62201015 -62314332
Locus: 11q12.3
Gene Diseases
The AHNAK RPS6KA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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