AHI1-CHEK2 Fusion FISH Probe
The AHI1-CHEK2 Fusion FISH Probe is used to confirm a fusion of the AHI1 and CHEK2 genes. The fusion of the AHI1 and CHEK2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AHI1-CHEK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-RERE | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-REOR | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-REGO | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-REGR | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-REAQ | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-ORRE | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-OROR | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-ORGO | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GORE | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GOOR | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GOGO | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GOGR | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GRRE | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GROR | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GRGO | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GRGR | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-AQRE | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-AQOR | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-AQGO | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-AQGR | 20 (40 μL) | 200 μL |
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| AHI1-CHEK2-20-AQAQ | 20 (40 μL) | 200 μL |
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CHEK2 Gene Summary
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: Checkpoint Kinase 2
Chromosome: CHR22: 29083730 -29137822
Locus: 22q12.1
AHI1 Gene Summary
This gene is apparently required for both cerebellar and cortical development in humans. This gene mutations cause specific forms of Joubert syndrome-related disorders. Joubert syndrome (JS) is a recessively inherited developmental brain disorder with several identified causative chromosomal loci. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Gene Name: Abelson Helper Integration Site 1
Chromosome: CHR6: 135605109 -135818903
Locus: 6q23.3
Gene Diseases
The AHI1 CHEK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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