AGR2-EIF2AK2 Fusion FISH Probe
The AGR2-EIF2AK2 Fusion FISH Probe is used to confirm a fusion of the AGR2 and EIF2AK2 genes. The fusion of the AGR2 and EIF2AK2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGR2-EIF2AK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-RERE | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-REOR | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-REGO | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-REGR | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-REAQ | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-ORRE | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-OROR | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-ORGO | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GORE | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GOOR | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GOGO | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GOGR | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GRRE | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GROR | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GRGO | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GRGR | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-AQRE | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-AQOR | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-AQGO | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-AQGR | 20 (40 μL) | 200 μL |
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| AGR2-EIF2AK2-20-AQAQ | 20 (40 μL) | 200 μL |
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EIF2AK2 Gene Summary
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2
Chromosome: CHR2: 37333698 -37384190
Locus: 2p22.2
AGR2 Gene Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]
Gene Name: Anterior Gradient 2, Protein Disulphide Isomerase Family Member
Chromosome: CHR7: 16832263 -16844738
Locus: 7p21.1
Gene Diseases
The AGR2 EIF2AK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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